Our external research program

We support pioneering research that advances science and improves patient lives. We value building our knowledge base and therapeutic outcomes by supporting independent and collaborative research with our medical and scientific peers.

This global external research program is open to all academic and community-based researchers who are interested in conducting their own research as investigator-initiated studies (IIS) or want to work in collaboration with BioCryst through external collaborative research (ECR). To submit a request, download the study concept form below.

Areas of interest for ECR


  • Real-world effectiveness and safety of berotralstat in patients who switched from other prophylactic therapies or are newly initiated on berotralstat
  • Patient-reported outcome measures for patients treated with berotralstat
  • Effectiveness of berotralstat in other bradykinin-mediated angioedemas
  • Novel outcomes or composite endpoints in patients treated with berotralstat


  • Burden of treatment and disease for patients living with hereditary angioedema (HAE)
  • Shared decision making in HAE
  • Diagnosis of HAE and other bradykinin-mediated angioedemas

For investigator-initiated studies (IIS) and ECR the investigator serves as the sponsor of the study and assumes responsibility for study design and protocol development, institutional and regulatory approvals and reporting requirements, study conduct as defined by all applicable local and regulatory requirements, and dissemination of study results in peer-reviewed publications.

The scientific review committee meets regularly to review all submissions and awards funding based on medical or scientific merit, study feasibility, and availability of funds. BioCryst may provide support for IIS/ECR in the form of funding and/or study drug, depending upon the type of research. Support of a clinical research study does not imply any obligation toward, or is in any way connected to, the recommendation or prescribing of BioCryst medicines.

IIS concept sheet >>  ECR concept sheet >>

Request for a medical education grant

If you have a scientific or medical idea and are seeking support, BioCryst invites you to submit an application for a medical educational grant. When submitting a request, you will be guided through the electronic submission process through instructions and help options. Submit a request >>

Special proposals and sponsorship requests

As a vital part of the medical community, we at BioCryst accept proposals for medical education grants, sponsorship requests, charitable contributions and/or donations, and patient advocacy charitable contributions. When submitting a request, you will be guided through the electronic submission process through instructions and help options. Submit a proposal >>

We are committed to advancing research, innovation, and training for healthcare professionals. The BioCryst HAE Fellowship Program will support 3rd Year Fellowship candidates at accredited, US-based academic institutions completing independent research focused on hereditary angioedema (HAE). Applications are no longer being accepted for this year. Please check back for updates and when the application process re-opens.