External Research Program

The mission of our External Research program is to improve the lives of our patients by increasing the medical and scientific understanding of our products and related therapeutic areas. BioCryst supports innovative disease-related research that will advance the science and improve patient outcomes. One way we can advance the knowledge base on disease state, disease management, and therapeutic outcomes is through support of independent and collaborative research.

This global program is open to all academic and community-based researchers who are interested in conducting their own research. This program allows investigators to submit proposals where they independently conduct research as Investigator Initiated Studies (IIS) or work in collaboration with BioCryst through External Collaborative Research (ECR).

Areas of Interest for External Collaborative Research (ECR):


  • Real-world effectiveness and safety of berotralstat in patients who switched from other prophylactic therapies or newly initiated on berotralstat
  • Patient-reported outcome measures for patients treated with berotralstat
  • Effectiveness of berotralstat in other bradykinin-mediated angioedemas
  • Novel outcomes or composite endpoints in patients treated with berotralstat

Disease specific

  • Burden of treatment and disease for patients living with HAE
  • Shared-decision making in HAE
  • Diagnosis of HAE and other bradykinin-mediated angioedemas

For IIS and ECR the investigator serves as the sponsor of the study and assumes responsibility for study design and protocol development, institutional and regulatory approvals and reporting requirements, study conduct as defined by all applicable local and regulatory requirements, and dissemination of study results in peer-reviewed publications.

The Scientific Review Committee meets regularly to review all submissions and awards funding based on medical or scientific merit, study feasibility, and availability of funds. BioCryst may provide support for IIS/ECR in the form of funding and/or study drug, depending upon the type of research. Support of a clinical research study does not imply any obligation toward, or is any way connected to, the recommendation or prescribing of BioCryst medicines.

To submit a request please download the study concept form and submit to externalresearchgrants@biocryst.com. If a concept is of interest, a request for full protocol submission will be issued.

For questions, please contact us.