BioCryst designs, optimizes and develops novel small-molecule drugs that block key enzymes involved in infectious and inflammatory diseases.
BioCryst uses state-of-the-art structure-guided drug design, which incorporates multiple scientific disciplines including biology, crystallography, medicinal chemistry and computer modeling, in order to most efficiently develop new therapeutic candidates.
BioCryst's current pipeline consists of the following development programs:
- Oral inhibitors of plasma kallikrein for hereditary angioedema; BCX4161 and a 2nd generation candidate
- BCX4430 a broad spectrum antiviral for development as a medical countermeasure against hemorrhagic fevers.
- Peramivir, a viral neuraminidase inhibitor developed under a HHS/BARDA contract as an intravenous antiviral for influenza until November 8, 2012, when enrollment in the Phase 3 Trial was suspended.
- Ulodesine (BCX4208), a Phase 3 ready purine nucleoside phosphorylase (PNP) inhibitor, in development as an add-on therapy for gout
BioCryst’s Approach to Building its Product Pipeline
BioCryst designs drug candidates using detailed knowledge of the structures of active sites of targeted enzymes. The active site of an enzyme is the area into which a chemical or biological molecule fits to initiate a biochemical reaction. Enzymes make ideal drug targets as they mediate biochemical processes along disease pathways, are relatively easy to crystallize, and have small active sites. BioCryst aims to license or design compounds that will fit in the active sites of enzymes and thereby interfere with the progression of disease. Using this approach, the Company has successfully both licensed and designed product candidates for infectious and inflammatory diseases.
Corporate & Academic Partnerships
The Company uses strategic partnerships early in the drug identification process through in-licensing of drug targets. BioCryst currently has collaborations with leading academic organizations including The University of Alabama at Birmingham and Albert Einstein College of Medicine of Yeshiva University and Industrial Research, Ltd., New Zealand. We have established collaborative relationships for development and commercialization of product candidates in their respective territories as follows:
- Shionogi & Co., Ltd. for peramivir in Japan and Taiwan
- Green Cross Corporation for peramivir in Korea
- Mundipharma International Holdings Limited has worldwide rights to develop and commercialize forodesine in the field of oncology
For more information regarding corporate and academic partnerships visit our Partners & Business Development page.